The Combination of Naltrexone and Bupropion for Weight Loss

In this article, we will discuss the combination of drugs Naltrexone and Bupropion and their use in weight loss. Naltrexone and Bupropion belong to different chemical and clinical categories but can be combined in a single tablet. They are available as extended-release tablets and are used in the management of chronic obesity and overweight patients with cardiovascular risk factors.

How the Combination Works

Within the central nervous system, Bupropion blocks dopamine transporters, increasing dopaminergic transmission. This leads to the activation of POMC neurons, which control appetite. Alpha-MSH, released by POMC, acts on melanocortin-4 receptors, reducing appetite and increasing energy consumption, resulting in weight loss. On the other hand, Naltrexone blocks mu receptors, removing the inhibitory effect of beta-endorphin on POMC activity, further reducing appetite.

Precautions and Side Effects

When using this combination, precautions should be taken in patients with a history of seizures, those using CNS stimulants, and those with previous head injury or stroke. The combination should be used cautiously with opioids to avoid opioid intoxication. Possible side effects include constipation, nausea, vomiting, headache, dizziness, insomnia, dry mouth, fatigue, tremor, hypertension, abdominal pain, tinnitus, excess sweating, and allergic reactions.

Dosage and Administration

The combination is available as an extended-release tablet containing 8 mg of Naltrexone hydrochloride and 90 mg of Bupropion hydrochloride. The dose should be slowly escalated over four weeks, starting with one tablet in the morning and gradually increasing to two tablets in the morning and evening. The maximum dose is 32 mg of Naltrexone and 360 mg of Bupropion. Therapy should be continued until the desired effectiveness is achieved.


The combination of Naltrexone and Bupropion is an effective option for the management of obesity. It works by reducing appetite and increasing energy consumption, leading to weight loss. However, precautions should be taken, and side effects should be monitored. Consult a healthcare professional before starting this treatment.

Leave a Comment